Efficacy of salmeterol xinafoate in the treatment of COPD. In this analysis, 24-hour Holter monitoring data were pooled from 2 identically designed Phase III trials. Production and hosting by Elsevier B.V. Egyptian Journal of Chest Diseases and Tuberculosis, https://doi.org/10.1016/j.ejcdt.2013.05.005. Albuterol metered dose inhaler (Ventolin inhalation aerosol, GlaxoSmithKline, Research Triangle Park, NC) and ipratropium metered dose inhaler (Atrovent inhalation aerosol, Boehringer Ingelheim, Ridgefield, CT) were provided as rescue and supplemental medications for COPD, respectively. While COPD is a mainly chronic disease, a substantial number of patients suffer from exacerbations. In another normative aging study among 423 healthy ambulatory adults aged 75-85 years followed for 10 years, Frishman et al12 reported a lower prevalence of paroxysmal atrial tachycardia (13%) than the current study, but a similar occurrence frequency (5%) of nonsustained ventricular tachycardia. Patients taking beta-blockers were also excluded. Emerging risk factors for the development of AF include a variety of breathing disorders like COPD. Two studies were conducted between February 2002 and March 2004 under United States Food and Drug Administration regulations, which include principles established by Good Clinical Practice and the Declaration of Helsinki and its amendments32. Finally, the initial Holter interpretations did not a priori place arrhythmias into the categories described in this report. Overall, the proportion of LABA-treated patients with treatment-emergent (i.e., not present at baseline) nonsustained ventricular tachycardia was similar to placebo (p = 0.86), and atrial fibrillation/flutter and >10 beat ventricular tachycardia were rarely observed in all groups (Table 4). In fact, the 3 more serious arrhythmia categories (afibrillation/flutter, nonsustained ventricular tachycardia, and >10 beat ventricular tachycardia) did occur in a significantly greater proportion of patients who did not receive study drug when compared to those who did. The most common arrhythmic events in the LABA treatment groups were tachycardia (0.3%-1.7% vs. 1.4% in the placebo group), ventricular extrasystoles (0.3%-1.7% vs 1.4% in the placebo group), and ventricular tachycardia (0.3%-1.0% vs. 1.4% in the placebo group) (Table 8). Chronic coughing at least three months out of the year for two consecutive years is a primary symptom of COPD. There is a high positive significant correlation between the age of patients, duration of COPD and Hb level and the occurrence of fatal arrhythmias where P values were 0.009, <0.0005 and <0.0005 respectively; the same as with QTd value where the P values were 0.015, 0.001 and 0.039. Glasser SP, Clark PI, Applebaum HJ. This heart rate reduction runs counter to the expected physiologic response to beta-agonists, and may suggest improved lung function or gas exchange associated with the use of inhaled beta-agonists in both the placebo and LABA groups in these trials. While most of these arrhythmias are benign and easily managed, some can become dangerous and difficult to treat. For more information, please refer to our Privacy Policy. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Arrhythmias in patients with chronic obstructive pulmonary disease. Because the study designs, patient populations, safety, and efficacy endpoints in each trial were identical, the data were combined to provide more stable estimates of infrequent arrhythmia events, such as atrial fibrillation and ventricular tachycardia, than either trial analyzed separately. Recommendations guiding physicians in biomedical research involving human subjects. Patients with MAT frequently have significant comorbidities, especially chronic obstructive pulmonary disease (COPD) and respiratory failure, and are often treated in ICUs. Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States. The number and percentage of patients who used rescue albuterol and supplemental ipratropium during the 24-hour Holter monitoring period were calculated for each assessment time. Heeringa J, van der Kuip DA, Hofman A, Kors JA, van HG, Stricker BH, Stijnen T, Lip GY, Witteman JC. This observation suggests either that COPD patients are less affected by atrial fibrillation than other elderly individuals, or, more likely, selection factors caused COPD patients with atrial fibrillation to be excluded from the current trial.

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